Prime-Boost Immunization with DNA Vaccine: Mucosal Route of Administration Changes the Rules

Changes the Rules Vaccine: Mucosal Route of Administration Prime-Boost Immunization with DNA

Prime-boost immunization with DNA vaccine: mucosal route of administration changes the rules.

In this study we assessed prime-boost immunization strategies with a DNA vaccine (gB DNA) and attenuated recombinant vaccinia virus vector (rvacgB), both encoding the gB protein of HSV, for their effectiveness at inducing mucosal as well as systemic immunity to HSV. Confirming the reports of others, systemic priming with gB DNA and systemic boosting with rvacgB were the most effective means of ...

Prime-Boost Strategies in Mucosal Immunization Affect Local IgA Production and the Type of Th Response

Combinations of different delivery routes for priming and boosting represent vaccination strategies that can modulate magnitude, quality, and localization of the immune response. A murine model was used to study T cell clonal expansion following intranasal (IN) or subcutaneous (SC) priming, and secondary immune responses after boosting by either homologous or heterologous routes. T cell primary...

Mucosal HIV-1 Pox Virus Prime-Boost

Prime-Boost with Alternating DNA Vaccines